Typically induction therapy is used to get the patient into remission quickly by reducing inflammation often for multiple weeks, e.g. infusion at 0, 2 and 6 weeks, to establish therapeutic levels of the medication followed by a maintenance regime every 8 weeks. The therapeutic effects typically last for weeks to months. Importantly, these drugs are not cures. They suppress the inflammation and require maintenance doses.
Some commonly used infusion therapies include:
Biologic medications: Biologics are a class of medications that target specific molecules involved in the immune system’s inflammatory response. Biologics have revolutionized the treatment of inflammatory bowel diseases. They are administered through infusion.
Examples include:
- Infliximab (Remicadeâ): This anti-TNF (tumor necrosis factor) biologic is given as an intravenous infusion over a period of time, typically in a medical setting. It can help reduce inflammation and induce and maintain remission in moderate to severe cases. Studies report that this is a very effective treatment option.
- Vedolizumab (Entyvioâ): This biologic medication targets the α4β7 integrin protein involved in immune cell migration. It is given as an intravenous infusion and is specifically approved for the treatment of moderate to severe cases. Studies report that this is a very effective treatment option for symptom remission.
Other intravenous medications: In some cases, other medications may be administered through intravenous infusion to manage the symptoms of severe inflammatory bowel diseases or induce remission. For example, corticosteroids such as methylprednisolone or hydrocortisone may be given intravenously during acute flare-ups to rapidly reduce inflammation.
Infusion therapy is usually conducted in a medical facility, such as a hospital or infusion center, under the supervision of healthcare professionals. The frequency and duration of infusion sessions depend on the specific medication and the individual’s treatment plan.